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Cell Free DNA

Cell Free DNA - . Cell Free DNA

Cell Free DNA

• In the cfDNA testing and analysis of plasma, it is a dependable field for disease diagnosis. Although healthy plasma has only few cfDNA, but the circulating cfDNA in the plasma is more or less relative with clinical diseases. • In the analysis process of plasmatic cfDNA, the sample management, transportation and processing are easily contaminated, leading to decomposition of nucleus blood cells, further release cell genetic DNA. At the same time, the reproduction of free DNA due to the activity of nuclease could lead to systemic problem. The additives in the cfDNA blood sampling could stabilize nucleus blood cells, in prevention of releasing cell genetic DNA, hence prohibits the decomposition of cfDNA nuclease trigger, which can further stabilize the whole stabilization of cfDNA. • cfDNA storage testing tube has antigen on the cell surface for protection. This is to maintain the cell shape, at the same time increase the chances of obtaining cfDNA, and its testing and analysis. In the collection of cfDNA storage testing sample, they are able to be stored under 6-37℃ for up to 10~14 days. This is good for sample collection, transportation and storage. cfDNA storage testing tube could be used in clinical study, pharmaceutical goods exploration and reinforce of diagnosis testing.

Recommendation

cfDNA is sourced for body cells damage. For a healthy individual, cfDNA are mainly sourced for normal metabolism of body cells. Therefore, relative low level are shown in the bloodstream. However, when there are major organ damage associated, large cells death leads to large quantity of cfDNA. Therefore, we are able to investigate through the quantity of cfDNA in the blood, to make further evaluation on categorization of diseases.

At present, there are many clinical studies which proved that systemic SLA such as rheumatoid arthritis, nephrotitis, pancreatitis, inflammation GI diseases, hepatitis.. etc. All the above mentioned patients have distinctively high cfDNA within their blood stream in comparison to healthy individuals.

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